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Excerpt — Biologic Regulation of Physical Activity

Physical activity levels: Familial and twin studies

The premise to be weighed in the pages that follow is this: There exists within the central nervous system an inherent control center that serves to regulate an individual’s daily energy expenditure by motor activity.

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Compensatory changes in physical activity

This is the originally proposed activity-stat concept: A set point for activity energy expenditure exists, such that any exercise intervention program would be met, or compensated for, by an equivalent amount of reduction of out-of-program activity and that the net change in activity energy expenditure would be zero.

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Plasticity of biologic set points

Biologic regulators that govern body physiologic functions are products of millions of years of evolutionary pressure. They should not, intuitively, be expected to be readily modifiable over time by extrinsic perturbations.

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